A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle characterized by otherwise unexplained thickening of the left ventricle. Left ventricular outflow tract (LVOT) obstruction is present in approximately two-thirds of patients and substantially increases the risk of disease...

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Detalles Bibliográficos
Autores principales: Stern, Joshua A., Markova, Svetlana, Ueda, Yu, Kim, Jae B., Pascoe, Peter J., Evanchik, Marc J., Green, Eric M., Harris, Samantha P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156432/
https://www.ncbi.nlm.nih.gov/pubmed/27973580
http://dx.doi.org/10.1371/journal.pone.0168407

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