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Biopharmaceuticals from microorganisms: from production to purification

The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons...

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Detalles Bibliográficos
Autores principales: Jozala, Angela Faustino, Geraldes, Danilo Costa, Tundisi, Louise Lacalendola, Feitosa, Valker de Araújo, Breyer, Carlos Alexandre, Cardoso, Samuel Leite, Mazzola, Priscila Gava, Oliveira-Nascimento, Laura de, Rangel-Yagui, Carlota de Oliveira, Magalhães, Pérola de Oliveira, Oliveira, Marcos Antonio de, Pessoa, Adalberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156500/
https://www.ncbi.nlm.nih.gov/pubmed/27838289
http://dx.doi.org/10.1016/j.bjm.2016.10.007
Descripción
Sumario:The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.