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Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-β Small Molecule Inhibitor()()

High-grade glioma (HGG), a deadly primary brain malignancy, manifests radioresistance mediated by cell-intrinsic and microenvironmental mechanisms. High levels of the cytokine transforming growth factor-β (TGF-β) in HGG promote radioresistance by enforcing an effective DNA damage response and suppor...

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Detalles Bibliográficos
Autores principales:	Bayin, N. Sumru, Ma, Lin, Thomas, Cheddhi, Baitalmal, Rabaa, Sure, Akhila, Fansiwala, Kush, Bustoros, Mark, Golfinos, John G., Pacione, Donato, Snuderl, Matija, Zagzag, David, Barcellos-Hoff, Mary Helen, Placantonakis, Dimitris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2016
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156509/ https://www.ncbi.nlm.nih.gov/pubmed/27978994 http://dx.doi.org/10.1016/j.neo.2016.08.008

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