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Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population

BACKGROUND: The aim of this study was to calculate 95% reference intervals and double-sided limits of serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) according to the CLSI EP28-A3 guideline. MATERIAL/METHODS: Serum AFP and CEA values were measured in samples from 26 000 healthy subj...

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Autores principales: Zhang, Gao-Ming, Guo, Xu-Xiao, Ma, Xiao-Bo, Zhang, Guo-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156556/
https://www.ncbi.nlm.nih.gov/pubmed/27941709
http://dx.doi.org/10.12659/MSM.901861
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author Zhang, Gao-Ming
Guo, Xu-Xiao
Ma, Xiao-Bo
Zhang, Guo-Ming
author_facet Zhang, Gao-Ming
Guo, Xu-Xiao
Ma, Xiao-Bo
Zhang, Guo-Ming
author_sort Zhang, Gao-Ming
collection PubMed
description BACKGROUND: The aim of this study was to calculate 95% reference intervals and double-sided limits of serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) according to the CLSI EP28-A3 guideline. MATERIAL/METHODS: Serum AFP and CEA values were measured in samples from 26 000 healthy subjects in the Shuyang area receiving general health checkups. The 95% reference intervals and upper limits were calculated by using MedCalc. RESULTS: We provided continuous reference intervals from 20 years old to 90 years old for AFP and CEA. The reference intervals were: AFP, 1.31–7.89 ng/ml (males) and 1.01–7.10 ng/ml (females); CEA, 0.51–4.86 ng/ml (males) and 0.35–3.45ng/ml (females). AFP and CEA were significantly positively correlated with age in both males (r=0.196 and r=0.198) and females (r=0.121 and r=0.197). CONCLUSIONS: Different races or populations and different detection systems may result in different reference intervals for AFP and CEA. Continuous reference intervals of age changes are more accurate than age groups.
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spelling pubmed-51565562016-12-20 Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population Zhang, Gao-Ming Guo, Xu-Xiao Ma, Xiao-Bo Zhang, Guo-Ming Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to calculate 95% reference intervals and double-sided limits of serum alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) according to the CLSI EP28-A3 guideline. MATERIAL/METHODS: Serum AFP and CEA values were measured in samples from 26 000 healthy subjects in the Shuyang area receiving general health checkups. The 95% reference intervals and upper limits were calculated by using MedCalc. RESULTS: We provided continuous reference intervals from 20 years old to 90 years old for AFP and CEA. The reference intervals were: AFP, 1.31–7.89 ng/ml (males) and 1.01–7.10 ng/ml (females); CEA, 0.51–4.86 ng/ml (males) and 0.35–3.45ng/ml (females). AFP and CEA were significantly positively correlated with age in both males (r=0.196 and r=0.198) and females (r=0.121 and r=0.197). CONCLUSIONS: Different races or populations and different detection systems may result in different reference intervals for AFP and CEA. Continuous reference intervals of age changes are more accurate than age groups. International Scientific Literature, Inc. 2016-12-12 /pmc/articles/PMC5156556/ /pubmed/27941709 http://dx.doi.org/10.12659/MSM.901861 Text en © Med Sci Monit, 2016 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Clinical Research
Zhang, Gao-Ming
Guo, Xu-Xiao
Ma, Xiao-Bo
Zhang, Guo-Ming
Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population
title Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population
title_full Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population
title_fullStr Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population
title_full_unstemmed Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population
title_short Reference Intervals of Alpha-Fetoprotein and Carcinoembryonic Antigen in the Apparently Healthy Population
title_sort reference intervals of alpha-fetoprotein and carcinoembryonic antigen in the apparently healthy population
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156556/
https://www.ncbi.nlm.nih.gov/pubmed/27941709
http://dx.doi.org/10.12659/MSM.901861
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