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Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants

BACKGROUND: Although Faecalibacterium prausnitzii is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear. METHODS: The counts of F. prausnitzii in the feces were examined by real-time...

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Autores principales: Koga, Yasuhiro, Tokunaga, Shouji, Nagano, Jun, Sato, Fuyuhiko, Konishi, Kenta, Tochio, Takumi, Murakami, Youko, Masumoto, Natsuko, Tezuka, Jun-ichirou, Sudo, Nobuyuki, Kubo, Chiharu, Shibata, Rumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156669/
https://www.ncbi.nlm.nih.gov/pubmed/27537603
http://dx.doi.org/10.1038/pr.2016.167
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author Koga, Yasuhiro
Tokunaga, Shouji
Nagano, Jun
Sato, Fuyuhiko
Konishi, Kenta
Tochio, Takumi
Murakami, Youko
Masumoto, Natsuko
Tezuka, Jun-ichirou
Sudo, Nobuyuki
Kubo, Chiharu
Shibata, Rumiko
author_facet Koga, Yasuhiro
Tokunaga, Shouji
Nagano, Jun
Sato, Fuyuhiko
Konishi, Kenta
Tochio, Takumi
Murakami, Youko
Masumoto, Natsuko
Tezuka, Jun-ichirou
Sudo, Nobuyuki
Kubo, Chiharu
Shibata, Rumiko
author_sort Koga, Yasuhiro
collection PubMed
description BACKGROUND: Although Faecalibacterium prausnitzii is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear. METHODS: The counts of F. prausnitzii in the feces were examined by real-time polymerase chain reaction (PCR). Fecal samples were obtained from 65 atopic dermatitis (AD) infants who participated in a randomized controlled clinical trial to investigate the therapeutic effect of kestose, the smallest fructooligosaccharide. RESULTS: Although the F. prausnitzii count was undetectable level in most 0- to 1-y-old infants, the count reached a level comparable to that in adults in 2- to 5-y-old infants. The bacterial number increased about 10-fold by oral administration of kestose every day for 12 wk in the younger infants, but not so much in the older infants. This bacterial increase was significantly correlated with an improvement in the AD symptoms in the older infants. CONCLUSION: The F. prausnitzii population in the intestine reaches a level comparable to that in adult at approximately 2 y of age. Kestose efficiently stimulates the growth of this bacterium in the intestine, which might lead to an improvement in AD symptoms in infants.
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spelling pubmed-51566692017-01-05 Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants Koga, Yasuhiro Tokunaga, Shouji Nagano, Jun Sato, Fuyuhiko Konishi, Kenta Tochio, Takumi Murakami, Youko Masumoto, Natsuko Tezuka, Jun-ichirou Sudo, Nobuyuki Kubo, Chiharu Shibata, Rumiko Pediatr Res Translational Investigation BACKGROUND: Although Faecalibacterium prausnitzii is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear. METHODS: The counts of F. prausnitzii in the feces were examined by real-time polymerase chain reaction (PCR). Fecal samples were obtained from 65 atopic dermatitis (AD) infants who participated in a randomized controlled clinical trial to investigate the therapeutic effect of kestose, the smallest fructooligosaccharide. RESULTS: Although the F. prausnitzii count was undetectable level in most 0- to 1-y-old infants, the count reached a level comparable to that in adults in 2- to 5-y-old infants. The bacterial number increased about 10-fold by oral administration of kestose every day for 12 wk in the younger infants, but not so much in the older infants. This bacterial increase was significantly correlated with an improvement in the AD symptoms in the older infants. CONCLUSION: The F. prausnitzii population in the intestine reaches a level comparable to that in adult at approximately 2 y of age. Kestose efficiently stimulates the growth of this bacterium in the intestine, which might lead to an improvement in AD symptoms in infants. Nature Publishing Group 2016-12 2016-09-21 /pmc/articles/PMC5156669/ /pubmed/27537603 http://dx.doi.org/10.1038/pr.2016.167 Text en Copyright © 2016 Official journal of the International Pediatric Research Foundation, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Translational Investigation
Koga, Yasuhiro
Tokunaga, Shouji
Nagano, Jun
Sato, Fuyuhiko
Konishi, Kenta
Tochio, Takumi
Murakami, Youko
Masumoto, Natsuko
Tezuka, Jun-ichirou
Sudo, Nobuyuki
Kubo, Chiharu
Shibata, Rumiko
Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
title Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
title_full Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
title_fullStr Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
title_full_unstemmed Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
title_short Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
title_sort age-associated effect of kestose on faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
topic Translational Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156669/
https://www.ncbi.nlm.nih.gov/pubmed/27537603
http://dx.doi.org/10.1038/pr.2016.167
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