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The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future
Parathyroid hormone (PTH) defends the extracellular fluid from hypocalcemia and has powerful and well-documented actions on the skeleton and renal tubular system. To achieve a satisfactory stable plasma calcium level, the secretion of PTH, and the resulting serum PTH level, is titrated carefully to...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156698/ https://www.ncbi.nlm.nih.gov/pubmed/28018229 http://dx.doi.org/10.3389/fphys.2016.00563 |
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author | Conigrave, Arthur D. |
author_facet | Conigrave, Arthur D. |
author_sort | Conigrave, Arthur D. |
collection | PubMed |
description | Parathyroid hormone (PTH) defends the extracellular fluid from hypocalcemia and has powerful and well-documented actions on the skeleton and renal tubular system. To achieve a satisfactory stable plasma calcium level, the secretion of PTH, and the resulting serum PTH level, is titrated carefully to the prevailing plasma ionized Ca(2+) concentration via a Ca(2+) sensing mechanism that mediates feedback inhibition of PTH secretion. Herein, I consider the properties of the parathyroid Ca(2+) sensing mechanism, the identity of the Ca(2+) sensor, the intracellular biochemical mechanisms that it controls, the manner of its integration with other components of the PTH secretion control mechanism, and its modulation by other nutrients. Together the well-established, recently elucidated, and yet-to-be discovered elements of the story constitute the past, present, and future of the parathyroid and its calcium-sensing receptor (CaSR). |
format | Online Article Text |
id | pubmed-5156698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51566982016-12-23 The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future Conigrave, Arthur D. Front Physiol Physiology Parathyroid hormone (PTH) defends the extracellular fluid from hypocalcemia and has powerful and well-documented actions on the skeleton and renal tubular system. To achieve a satisfactory stable plasma calcium level, the secretion of PTH, and the resulting serum PTH level, is titrated carefully to the prevailing plasma ionized Ca(2+) concentration via a Ca(2+) sensing mechanism that mediates feedback inhibition of PTH secretion. Herein, I consider the properties of the parathyroid Ca(2+) sensing mechanism, the identity of the Ca(2+) sensor, the intracellular biochemical mechanisms that it controls, the manner of its integration with other components of the PTH secretion control mechanism, and its modulation by other nutrients. Together the well-established, recently elucidated, and yet-to-be discovered elements of the story constitute the past, present, and future of the parathyroid and its calcium-sensing receptor (CaSR). Frontiers Media S.A. 2016-12-15 /pmc/articles/PMC5156698/ /pubmed/28018229 http://dx.doi.org/10.3389/fphys.2016.00563 Text en Copyright © 2016 Conigrave. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Conigrave, Arthur D. The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future |
title | The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future |
title_full | The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future |
title_fullStr | The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future |
title_full_unstemmed | The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future |
title_short | The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future |
title_sort | calcium-sensing receptor and the parathyroid: past, present, future |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156698/ https://www.ncbi.nlm.nih.gov/pubmed/28018229 http://dx.doi.org/10.3389/fphys.2016.00563 |
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