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Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission

Cytomegalovirus (CMV) is one of the most common infectious agents, infecting the general population at an early age without causing morbidity most of the time. However, on particular occasions, it may represent a serious risk, as active infection is associated with rejection and disease after solid...

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Detalles Bibliográficos
Autores principales: Freer, Giulia, Quaranta, Paola, Pistello, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156801/
https://www.ncbi.nlm.nih.gov/pubmed/28044143
http://dx.doi.org/10.1155/2016/9384813
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author Freer, Giulia
Quaranta, Paola
Pistello, Mauro
author_facet Freer, Giulia
Quaranta, Paola
Pistello, Mauro
author_sort Freer, Giulia
collection PubMed
description Cytomegalovirus (CMV) is one of the most common infectious agents, infecting the general population at an early age without causing morbidity most of the time. However, on particular occasions, it may represent a serious risk, as active infection is associated with rejection and disease after solid organ transplantation or fetal transmission during pregnancy. Several methods for CMV diagnosis are available on the market, but because infection is so common, careful selection is needed to discriminate primary infection from reactivation. This review focuses on methods based on CMV-specific T cell reactivity to help monitor the consequences of CMV infection/reactivation in specific categories of patients. This review makes an attempt at discussing the pros and cons of the methods available.
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spelling pubmed-51568012017-01-02 Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission Freer, Giulia Quaranta, Paola Pistello, Mauro J Immunol Res Review Article Cytomegalovirus (CMV) is one of the most common infectious agents, infecting the general population at an early age without causing morbidity most of the time. However, on particular occasions, it may represent a serious risk, as active infection is associated with rejection and disease after solid organ transplantation or fetal transmission during pregnancy. Several methods for CMV diagnosis are available on the market, but because infection is so common, careful selection is needed to discriminate primary infection from reactivation. This review focuses on methods based on CMV-specific T cell reactivity to help monitor the consequences of CMV infection/reactivation in specific categories of patients. This review makes an attempt at discussing the pros and cons of the methods available. Hindawi Publishing Corporation 2016 2016-12-01 /pmc/articles/PMC5156801/ /pubmed/28044143 http://dx.doi.org/10.1155/2016/9384813 Text en Copyright © 2016 Giulia Freer et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Freer, Giulia
Quaranta, Paola
Pistello, Mauro
Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission
title Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission
title_full Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission
title_fullStr Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission
title_full_unstemmed Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission
title_short Evaluation of T Cell Immunity against Human Cytomegalovirus: Impact on Patient Management and Risk Assessment of Vertical Transmission
title_sort evaluation of t cell immunity against human cytomegalovirus: impact on patient management and risk assessment of vertical transmission
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156801/
https://www.ncbi.nlm.nih.gov/pubmed/28044143
http://dx.doi.org/10.1155/2016/9384813
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