APP Causes Hyperexcitability in Fragile X Mice

Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1(KO) mice. Normalization of APP levels in Fmr1(KO) mice (Fmr1(KO)/APP(HET) mice) rescues many disease phenotypes. Thus, APP is a potential biomarker...

Descripción completa

Detalles Bibliográficos
Autores principales: Westmark, Cara J., Chuang, Shih-Chieh, Hays, Seth A., Filon, Mikolaj J., Ray, Brian C., Westmark, Pamela R., Gibson, Jay R., Huber, Kimberly M., Wong, Robert K. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156834/
https://www.ncbi.nlm.nih.gov/pubmed/28018172
http://dx.doi.org/10.3389/fnmol.2016.00147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156834/
https://www.ncbi.nlm.nih.gov/pubmed/28018172
http://dx.doi.org/10.3389/fnmol.2016.00147

Ejemplares similares