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APP Causes Hyperexcitability in Fragile X Mice

Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1(KO) mice. Normalization of APP levels in Fmr1(KO) mice (Fmr1(KO)/APP(HET) mice) rescues many disease phenotypes. Thus, APP is a potential biomarker...

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Detalles Bibliográficos
Autores principales:	Westmark, Cara J., Chuang, Shih-Chieh, Hays, Seth A., Filon, Mikolaj J., Ray, Brian C., Westmark, Pamela R., Gibson, Jay R., Huber, Kimberly M., Wong, Robert K. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156834/ https://www.ncbi.nlm.nih.gov/pubmed/28018172 http://dx.doi.org/10.3389/fnmol.2016.00147

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