Cargando…

AECHL-1 targets breast cancer progression via inhibition of metastasis, prevention of EMT and suppression of Cancer Stem Cell characteristics

Triple negative breast cancer (TNBC) features among the most aggressive manifestations of cancer due to its enhanced metastatic potential and immunity to therapeutics which target hormone receptors. Under such scenarios, anti-cancer compounds with an ability to influence multiple targets, or an enti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dasgupta, Aparajita, Sawant, Mithila A., Kavishwar, Gayatri, Lavhale, Manish, Sitasawad, Sandhya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156909/ https://www.ncbi.nlm.nih.gov/pubmed/27974826 http://dx.doi.org/10.1038/srep38045

Ejemplares similares

AECHL-1, a novel triterpenoid, targets tumor neo-vasculature and impairs the endothelial cell cytoskeleton
por: Dasgupta, Aparajita, et al.
Publicado: (2015)

A Novel Triterpenoid Isolated from the Root Bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a Potential Anti-Cancer Agent
por: Lavhale, Manish S., et al.
Publicado: (2009)

A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca(2+) transients and prevents cardiac cell death through restoration of mitochondrial function
por: Kain, Vasundhara, et al.
Publicado: (2016)

miR-140-5p Attenuates Hypoxia-Induced Breast Cancer Progression by Targeting Nrf2/HO-1 Axis in a Keap1-Independent Mechanism
por: Mahajan, Megharani, et al.
Publicado: (2021)

Retraction: A Novel Triterpenoid Isolated from the Root Bark of Ailanthus excelsa Roxb (Tree of Heaven), AECHL-1 as a Potential Anti-Cancer Agent
Publicado: (2020)

Disconnect between EMT and metastasis in pancreas cancer
por: Whittle, Martin C., et al.
Publicado: (2015)

Context-dependent EMT programs in cancer metastasis
por: Aiello, Nicole M., et al.
Publicado: (2019)

Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells
por: Kamble, Dinisha, et al.
Publicado: (2021)

Prefoldin 1 promotes EMT and lung cancer progression by suppressing cyclin A expression
por: Wang, D, et al.
Publicado: (2017)

Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis
por: Kain, Vasundhara, et al.
Publicado: (2011)

Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
por: Tan, Zhuomin, et al.
Publicado: (2022)

GDF15 promotes EMT and metastasis in colorectal cancer
por: Li, Chen, et al.
Publicado: (2015)

Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis
por: Vu, Trung, et al.
Publicado: (2017)

EMT Mechanism, Lung Cancer Metastasis, and microRNA
por: Tanabe, Shihori
Publicado: (2021)

Aspects of the Epigenetic Regulation of EMT Related to Cancer Metastasis
por: Nowak, Ewa, et al.
Publicado: (2021)

Chemokine/GPCR Signaling-Mediated EMT in Cancer Metastasis
por: Tian, Xutengyue, et al.
Publicado: (2022)

FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs
por: Suh, Sung-Suk, et al.
Publicado: (2014)

HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer
por: Rumman, Marufa, et al.
Publicado: (2016)

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
por: Huang, Yuhe, et al.
Publicado: (2022)

PRELIMINARY PHYTOCHEMICAL STUDIES ON THE ROOTS OF COCCULUS HIRSUTUS, LINN.
por: Jain, Sourabh, et al.
Publicado: (2004)

EMT and tumor metastasis
por: Heerboth, Sarah, et al.
Publicado: (2015)

GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway
por: Liu, Ying, et al.
Publicado: (2021)

EMT and inflammation: inseparable actors of cancer progression
por: Suarez‐Carmona, Meggy, et al.
Publicado: (2017)

Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT
por: Parvani, Jenny G, et al.
Publicado: (2013)

Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer
por: Brown, Meredith S., et al.
Publicado: (2022)

Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms
por: Li, Dandan, et al.
Publicado: (2023)

CDX2 as a Predictive Biomarker Involved in Immunotherapy Response Suppresses Metastasis through EMT in Colorectal Cancer
por: Wang, Yun-shuai, et al.
Publicado: (2022)

IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF-κB signaling pathway
por: Wang, Mengxue, et al.
Publicado: (2023)

FORMULATION AND EVALUATION OF RICE BRAN WAX AS OINTMENT BASE
por: Bhalekar, M, et al.
Publicado: (2004)

EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer
por: Zheng, Xiaofeng, et al.
Publicado: (2015)

A landscape view on the interplay between EMT and cancer metastasis
por: Li, Chunhe, et al.
Publicado: (2018)

AURKB Promotes the Metastasis of Gastric Cancer, Possibly by Inducing EMT
por: Wang, Zhen, et al.
Publicado: (2020)

DSTYK Promotes Metastasis and Chemoresistance via EMT in Colorectal Cancer
por: Zhang, Jinyu, et al.
Publicado: (2020)

FRA-1 as a Regulator of EMT and Metastasis in Breast Cancer
por: Casalino, Laura, et al.
Publicado: (2023)

Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
por: Tan, Tingshan, et al.
Publicado: (2022)

LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway
por: Xu, Yihui, et al.
Publicado: (2022)

Targeting LncRNA HOTAIR suppresses cancer stemness and metastasis in oral carcinomas stem cells through modulation of EMT
por: Lu, Ming-Yi, et al.
Publicado: (2017)

MicroRNAs: regulators of cancer metastasis and epithelial-mesenchymal transition (EMT)
por: Ding, Xiang-Ming
Publicado: (2014)

NEK4 kinase regulates EMT to promote lung cancer metastasis
por: Ding, Nian‐Hua, et al.
Publicado: (2018)

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer
por: Recouvreux, Maria Victoria, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8q9mqicqfugvf42lco4m206mkr