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High-order synchronization of hair cell bundles
Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A na...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156917/ https://www.ncbi.nlm.nih.gov/pubmed/27974743 http://dx.doi.org/10.1038/srep39116 |
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author | Levy, Michael Molzon, Adrian Lee, Jae-Hyun Kim, Ji-wook Cheon, Jinwoo Bozovic, Dolores |
author_facet | Levy, Michael Molzon, Adrian Lee, Jae-Hyun Kim, Ji-wook Cheon, Jinwoo Bozovic, Dolores |
author_sort | Levy, Michael |
collection | PubMed |
description | Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A nanomagnetic technique is used to stimulate the bundles without an imposed mechanical load. The evoked response shows regimes of high-order mode-locking. Exploring a broad range of stimulus frequencies and intensities, we observe regions of high-order synchronization, analogous to Arnold Tongues in dynamical systems literature. Significant areas of overlap occur between synchronization regimes, with the bundle intermittently flickering between different winding numbers. We demonstrate how an ensemble of these noisy spontaneous oscillators could be entrained to efficiently detect signals significantly above the characteristic frequencies of the individual cells. |
format | Online Article Text |
id | pubmed-5156917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51569172016-12-20 High-order synchronization of hair cell bundles Levy, Michael Molzon, Adrian Lee, Jae-Hyun Kim, Ji-wook Cheon, Jinwoo Bozovic, Dolores Sci Rep Article Auditory and vestibular hair cell bundles exhibit active mechanical oscillations at natural frequencies that are typically lower than the detection range of the corresponding end organs. We explore how these noisy nonlinear oscillators mode-lock to frequencies higher than their internal clocks. A nanomagnetic technique is used to stimulate the bundles without an imposed mechanical load. The evoked response shows regimes of high-order mode-locking. Exploring a broad range of stimulus frequencies and intensities, we observe regions of high-order synchronization, analogous to Arnold Tongues in dynamical systems literature. Significant areas of overlap occur between synchronization regimes, with the bundle intermittently flickering between different winding numbers. We demonstrate how an ensemble of these noisy spontaneous oscillators could be entrained to efficiently detect signals significantly above the characteristic frequencies of the individual cells. Nature Publishing Group 2016-12-15 /pmc/articles/PMC5156917/ /pubmed/27974743 http://dx.doi.org/10.1038/srep39116 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Levy, Michael Molzon, Adrian Lee, Jae-Hyun Kim, Ji-wook Cheon, Jinwoo Bozovic, Dolores High-order synchronization of hair cell bundles |
title | High-order synchronization of hair cell bundles |
title_full | High-order synchronization of hair cell bundles |
title_fullStr | High-order synchronization of hair cell bundles |
title_full_unstemmed | High-order synchronization of hair cell bundles |
title_short | High-order synchronization of hair cell bundles |
title_sort | high-order synchronization of hair cell bundles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156917/ https://www.ncbi.nlm.nih.gov/pubmed/27974743 http://dx.doi.org/10.1038/srep39116 |
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