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Roles of human POLD1 and POLD3 in genome stability

DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of genome instability, frequently associated with cancer and aging. POLD1 is the catalytic subunit and POLD3 is an accessory subunit of the replicative Pol δ polymerase, which also func...

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Detalles Bibliográficos
Autores principales: Tumini, Emanuela, Barroso, Sonia, -Calero, Carmen Pérez, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156928/
https://www.ncbi.nlm.nih.gov/pubmed/27974823
http://dx.doi.org/10.1038/srep38873

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