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Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli

Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC), which has a better prognosis, is seen mostly in the setting of familial adenomatous polyposis (FAP). The cytomorphology of CMV-PTC is diverse; hence, it could be mistaken for other thyroid neoplasms with bad prognostic outcome. Thi...

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Autores principales: Priyani, Amarathunga AH, Opatha, Shamika T, Gunathilake, Nisayuri W, Lokuhetty, Menaka DS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156991/
https://www.ncbi.nlm.nih.gov/pubmed/28028343
http://dx.doi.org/10.4103/0970-9371.190450
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author Priyani, Amarathunga AH
Opatha, Shamika T
Gunathilake, Nisayuri W
Lokuhetty, Menaka DS
author_facet Priyani, Amarathunga AH
Opatha, Shamika T
Gunathilake, Nisayuri W
Lokuhetty, Menaka DS
author_sort Priyani, Amarathunga AH
collection PubMed
description Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC), which has a better prognosis, is seen mostly in the setting of familial adenomatous polyposis (FAP). The cytomorphology of CMV-PTC is diverse; hence, it could be mistaken for other thyroid neoplasms with bad prognostic outcome. This case is of a 24-year-old female diagnosed with polyposis coli found to have thyroid nodules at screening ultrasonography. Aspirated thyroid smears were hypercellular with epithelial cells arranged in monolayer sheets, papillae with discohesion, and spindling of cells at the edges, cribriform clusters, and cell morules. Individual cell morphology ranged from polygonal, tall columnar to spindle cells. Nuclei were round-to-oval with coarse chromatin, indistinct nucleoli, and mitotic figures. Nuclear inclusions and grooves were rare and colloid was sparse. Cytomorphology was suspicious, however, was not classical of CMV-PTC documented so far. Subsequent histology confirmed a CMV-PTC.
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spelling pubmed-51569912016-12-27 Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli Priyani, Amarathunga AH Opatha, Shamika T Gunathilake, Nisayuri W Lokuhetty, Menaka DS J Cytol Case Report Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC), which has a better prognosis, is seen mostly in the setting of familial adenomatous polyposis (FAP). The cytomorphology of CMV-PTC is diverse; hence, it could be mistaken for other thyroid neoplasms with bad prognostic outcome. This case is of a 24-year-old female diagnosed with polyposis coli found to have thyroid nodules at screening ultrasonography. Aspirated thyroid smears were hypercellular with epithelial cells arranged in monolayer sheets, papillae with discohesion, and spindling of cells at the edges, cribriform clusters, and cell morules. Individual cell morphology ranged from polygonal, tall columnar to spindle cells. Nuclei were round-to-oval with coarse chromatin, indistinct nucleoli, and mitotic figures. Nuclear inclusions and grooves were rare and colloid was sparse. Cytomorphology was suspicious, however, was not classical of CMV-PTC documented so far. Subsequent histology confirmed a CMV-PTC. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5156991/ /pubmed/28028343 http://dx.doi.org/10.4103/0970-9371.190450 Text en Copyright: © 2016 Journal of Cytology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Priyani, Amarathunga AH
Opatha, Shamika T
Gunathilake, Nisayuri W
Lokuhetty, Menaka DS
Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli
title Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli
title_full Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli
title_fullStr Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli
title_full_unstemmed Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli
title_short Cribriform morular variant of papillary thyroid carcinoma: Cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli
title_sort cribriform morular variant of papillary thyroid carcinoma: cytomorphology, differential diagnosis and diagnostic implications in patients with adenomatous polyposis coli
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156991/
https://www.ncbi.nlm.nih.gov/pubmed/28028343
http://dx.doi.org/10.4103/0970-9371.190450
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