FGFR1 and NTRK3 actionable alterations in “Wild-Type” gastrointestinal stromal tumors

BACKGROUND: About 10–15% of adult, and most pediatric, gastrointestinal stromal tumors (GIST) lack mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF1). The identification of additional mutated genes in this rare subset of tumors can have important clinical benefit to identify...

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Detalles Bibliográficos
Autores principales: Shi, Eileen, Chmielecki, Juliann, Tang, Chih-Min, Wang, Kai, Heinrich, Michael C., Kang, Guhyun, Corless, Christopher L., Hong, David, Fero, Katherine E., Murphy, James D., Fanta, Paul T., Ali, Siraj M., De Siena, Martina, Burgoyne, Adam M., Movva, Sujana, Madlensky, Lisa, Heestand, Gregory M., Trent, Jonathan C., Kurzrock, Razelle, Morosini, Deborah, Ross, Jeffrey S., Harismendy, Olivier, Sicklick, Jason K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157084/
https://www.ncbi.nlm.nih.gov/pubmed/27974047
http://dx.doi.org/10.1186/s12967-016-1075-6

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