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The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

The interplay between methylation and demethylation of histone lysine residues is an essential component of gene expression regulation and there is considerable interest in elucidating the roles of proteins involved. Here we report that histone demethylase KDM4A/JMJD2A, which is involved in the regu...

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Autores principales: Salifou, Kader, Ray, Swagat, Verrier, Laure, Aguirrebengoa, Marion, Trouche, Didier, Panov, Konstantin I., Vandromme, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157185/
https://www.ncbi.nlm.nih.gov/pubmed/26729372
http://dx.doi.org/10.1038/ncomms10174
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author Salifou, Kader
Ray, Swagat
Verrier, Laure
Aguirrebengoa, Marion
Trouche, Didier
Panov, Konstantin I.
Vandromme, Marie
author_facet Salifou, Kader
Ray, Swagat
Verrier, Laure
Aguirrebengoa, Marion
Trouche, Didier
Panov, Konstantin I.
Vandromme, Marie
author_sort Salifou, Kader
collection PubMed
description The interplay between methylation and demethylation of histone lysine residues is an essential component of gene expression regulation and there is considerable interest in elucidating the roles of proteins involved. Here we report that histone demethylase KDM4A/JMJD2A, which is involved in the regulation of cell proliferation and is overexpressed in some cancers, interacts with RNA Polymerase I, associates with active ribosomal RNA genes and is required for serum-induced activation of rDNA transcription. We propose that KDM4A controls the initial stages of transition from ‘poised', non-transcribed rDNA chromatin into its active form. We show that PI3K, a major signalling transducer central for cell proliferation and survival, controls cellular localization of KDM4A and consequently its association with ribosomal DNA through the SGK1 downstream kinase. We propose that the interplay between PI3K/SGK1 signalling cascade and KDM4A constitutes a mechanism by which cells adapt ribosome biogenesis level to the availability of growth factors and nutrients.
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spelling pubmed-51571852017-01-05 The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability Salifou, Kader Ray, Swagat Verrier, Laure Aguirrebengoa, Marion Trouche, Didier Panov, Konstantin I. Vandromme, Marie Nat Commun Article The interplay between methylation and demethylation of histone lysine residues is an essential component of gene expression regulation and there is considerable interest in elucidating the roles of proteins involved. Here we report that histone demethylase KDM4A/JMJD2A, which is involved in the regulation of cell proliferation and is overexpressed in some cancers, interacts with RNA Polymerase I, associates with active ribosomal RNA genes and is required for serum-induced activation of rDNA transcription. We propose that KDM4A controls the initial stages of transition from ‘poised', non-transcribed rDNA chromatin into its active form. We show that PI3K, a major signalling transducer central for cell proliferation and survival, controls cellular localization of KDM4A and consequently its association with ribosomal DNA through the SGK1 downstream kinase. We propose that the interplay between PI3K/SGK1 signalling cascade and KDM4A constitutes a mechanism by which cells adapt ribosome biogenesis level to the availability of growth factors and nutrients. Nature Publishing Group 2016-01-05 /pmc/articles/PMC5157185/ /pubmed/26729372 http://dx.doi.org/10.1038/ncomms10174 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Salifou, Kader
Ray, Swagat
Verrier, Laure
Aguirrebengoa, Marion
Trouche, Didier
Panov, Konstantin I.
Vandromme, Marie
The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_full The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_fullStr The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_full_unstemmed The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_short The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability
title_sort histone demethylase jmjd2a/kdm4a links ribosomal rna transcription to nutrients and growth factors availability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157185/
https://www.ncbi.nlm.nih.gov/pubmed/26729372
http://dx.doi.org/10.1038/ncomms10174
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