Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling

We present data on the evolution of intrinsically disordered regions (IDRs) taking into account the entire human protein kinome. The evolutionary data of the IDRs with respect to the kinase domains (KDs) and kinases as a whole protein (WP) are reported. Further, we have reported its post translation...

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Autores principales: Kathiriya, Jaymin J., Pathak, Ravi Ramesh, Bezginov, Alexandr, Xue, Bin, Uversky, Vladimir N., Tillier, Elisabeth R.M., Davé, Vrushank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157709/
https://www.ncbi.nlm.nih.gov/pubmed/28004021
http://dx.doi.org/10.1016/j.dib.2016.11.099
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author Kathiriya, Jaymin J.
Pathak, Ravi Ramesh
Bezginov, Alexandr
Xue, Bin
Uversky, Vladimir N.
Tillier, Elisabeth R.M.
Davé, Vrushank
author_facet Kathiriya, Jaymin J.
Pathak, Ravi Ramesh
Bezginov, Alexandr
Xue, Bin
Uversky, Vladimir N.
Tillier, Elisabeth R.M.
Davé, Vrushank
author_sort Kathiriya, Jaymin J.
collection PubMed
description We present data on the evolution of intrinsically disordered regions (IDRs) taking into account the entire human protein kinome. The evolutionary data of the IDRs with respect to the kinase domains (KDs) and kinases as a whole protein (WP) are reported. Further, we have reported its post translational modifications of FAK1 IDRs and their contribution to the cytoskeletal remodeling. We also report the data to build a protein-protein interaction (PPI) network of primary and secondary FAK1-interacting hybrid proteins. Detailed analysis of the data and its effect on FAK1-related functions have been described in “Structural pliability adjacent to the kinase domain highlights contribution of FAK1 IDRs to cytoskeletal remodeling” (Kathiriya et. al., 2016) [1].
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spelling pubmed-51577092016-12-21 Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling Kathiriya, Jaymin J. Pathak, Ravi Ramesh Bezginov, Alexandr Xue, Bin Uversky, Vladimir N. Tillier, Elisabeth R.M. Davé, Vrushank Data Brief Data Article We present data on the evolution of intrinsically disordered regions (IDRs) taking into account the entire human protein kinome. The evolutionary data of the IDRs with respect to the kinase domains (KDs) and kinases as a whole protein (WP) are reported. Further, we have reported its post translational modifications of FAK1 IDRs and their contribution to the cytoskeletal remodeling. We also report the data to build a protein-protein interaction (PPI) network of primary and secondary FAK1-interacting hybrid proteins. Detailed analysis of the data and its effect on FAK1-related functions have been described in “Structural pliability adjacent to the kinase domain highlights contribution of FAK1 IDRs to cytoskeletal remodeling” (Kathiriya et. al., 2016) [1]. Elsevier 2016-12-08 /pmc/articles/PMC5157709/ /pubmed/28004021 http://dx.doi.org/10.1016/j.dib.2016.11.099 Text en © 2017 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Kathiriya, Jaymin J.
Pathak, Ravi Ramesh
Bezginov, Alexandr
Xue, Bin
Uversky, Vladimir N.
Tillier, Elisabeth R.M.
Davé, Vrushank
Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
title Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
title_full Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
title_fullStr Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
title_full_unstemmed Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
title_short Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
title_sort data on evolution of intrinsically disordered regions of the human kinome and contribution of fak1 idrs to cytoskeletal remodeling
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157709/
https://www.ncbi.nlm.nih.gov/pubmed/28004021
http://dx.doi.org/10.1016/j.dib.2016.11.099
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