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Clinical trials in low and middle-income countries — Successes and challenges

Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a n...

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Autores principales: Grover, Surbhi, Xu, Melody, Jhingran, Anuja, Mahantshetty, Umesh, Chuang, Linus, Small, William, Gaffney, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157789/
https://www.ncbi.nlm.nih.gov/pubmed/28004030
http://dx.doi.org/10.1016/j.gore.2016.11.007
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author Grover, Surbhi
Xu, Melody
Jhingran, Anuja
Mahantshetty, Umesh
Chuang, Linus
Small, William
Gaffney, David
author_facet Grover, Surbhi
Xu, Melody
Jhingran, Anuja
Mahantshetty, Umesh
Chuang, Linus
Small, William
Gaffney, David
author_sort Grover, Surbhi
collection PubMed
description Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea. In this article we describe the challenges involved in initiating clinical trials in LMICs, review current efforts within surgical, medical, and radiation oncology, and introduce high priority topics for future research.
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spelling pubmed-51577892016-12-21 Clinical trials in low and middle-income countries — Successes and challenges Grover, Surbhi Xu, Melody Jhingran, Anuja Mahantshetty, Umesh Chuang, Linus Small, William Gaffney, David Gynecol Oncol Rep Review Article Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea. In this article we describe the challenges involved in initiating clinical trials in LMICs, review current efforts within surgical, medical, and radiation oncology, and introduce high priority topics for future research. Elsevier 2016-11-25 /pmc/articles/PMC5157789/ /pubmed/28004030 http://dx.doi.org/10.1016/j.gore.2016.11.007 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Grover, Surbhi
Xu, Melody
Jhingran, Anuja
Mahantshetty, Umesh
Chuang, Linus
Small, William
Gaffney, David
Clinical trials in low and middle-income countries — Successes and challenges
title Clinical trials in low and middle-income countries — Successes and challenges
title_full Clinical trials in low and middle-income countries — Successes and challenges
title_fullStr Clinical trials in low and middle-income countries — Successes and challenges
title_full_unstemmed Clinical trials in low and middle-income countries — Successes and challenges
title_short Clinical trials in low and middle-income countries — Successes and challenges
title_sort clinical trials in low and middle-income countries — successes and challenges
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157789/
https://www.ncbi.nlm.nih.gov/pubmed/28004030
http://dx.doi.org/10.1016/j.gore.2016.11.007
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