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Clinical trials in low and middle-income countries — Successes and challenges
Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a n...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157789/ https://www.ncbi.nlm.nih.gov/pubmed/28004030 http://dx.doi.org/10.1016/j.gore.2016.11.007 |
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author | Grover, Surbhi Xu, Melody Jhingran, Anuja Mahantshetty, Umesh Chuang, Linus Small, William Gaffney, David |
author_facet | Grover, Surbhi Xu, Melody Jhingran, Anuja Mahantshetty, Umesh Chuang, Linus Small, William Gaffney, David |
author_sort | Grover, Surbhi |
collection | PubMed |
description | Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea. In this article we describe the challenges involved in initiating clinical trials in LMICs, review current efforts within surgical, medical, and radiation oncology, and introduce high priority topics for future research. |
format | Online Article Text |
id | pubmed-5157789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-51577892016-12-21 Clinical trials in low and middle-income countries — Successes and challenges Grover, Surbhi Xu, Melody Jhingran, Anuja Mahantshetty, Umesh Chuang, Linus Small, William Gaffney, David Gynecol Oncol Rep Review Article Gynecologic malignancies affect women in low and middle-income countries (LMICs) at equal or higher rates compared to high income countries (HICs), yet practice guidelines based on clinical trials performed in HICs do not routinely account for resource disparities between these regions. There is a need and growing interest for executing clinical trials in LMICs. This has led to the creation of multinational cooperative groups and the initiation of several ongoing clinical trials in Mexico, China, and Korea. In this article we describe the challenges involved in initiating clinical trials in LMICs, review current efforts within surgical, medical, and radiation oncology, and introduce high priority topics for future research. Elsevier 2016-11-25 /pmc/articles/PMC5157789/ /pubmed/28004030 http://dx.doi.org/10.1016/j.gore.2016.11.007 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Grover, Surbhi Xu, Melody Jhingran, Anuja Mahantshetty, Umesh Chuang, Linus Small, William Gaffney, David Clinical trials in low and middle-income countries — Successes and challenges |
title | Clinical trials in low and middle-income countries — Successes and challenges |
title_full | Clinical trials in low and middle-income countries — Successes and challenges |
title_fullStr | Clinical trials in low and middle-income countries — Successes and challenges |
title_full_unstemmed | Clinical trials in low and middle-income countries — Successes and challenges |
title_short | Clinical trials in low and middle-income countries — Successes and challenges |
title_sort | clinical trials in low and middle-income countries — successes and challenges |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157789/ https://www.ncbi.nlm.nih.gov/pubmed/28004030 http://dx.doi.org/10.1016/j.gore.2016.11.007 |
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