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TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells

Aberrant DNA methylation is commonly observed in colorectal cancer (CRC), but the underlying mechanism is not fully understood. 5-hydroxymethylcytosine levels and TET1 expression are both reduced in CRC, while epigenetic silencing of TET1 is reportedly associated with the CpG island methylator pheno...

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Detalles Bibliográficos
Autores principales:	Kai, Masahiro, Niinuma, Takeshi, Kitajima, Hiroshi, Yamamoto, Eiichiro, Harada, Taku, Aoki, Hironori, Maruyama, Reo, Toyota, Mutsumi, Sasaki, Yasushi, Sugai, Tamotsu, Tokino, Takashi, Nakase, Hiroshi, Suzuki, Hiromu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158030/ https://www.ncbi.nlm.nih.gov/pubmed/27977763 http://dx.doi.org/10.1371/journal.pone.0168281

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