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Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication
Approximately 30% of tumor endothelial cells have over-duplicated (>2) centrosomes, which may contribute to abnormal vessel function and drug resistance. Elevated levels of vascular endothelial growth factor A induce excess centrosomes in endothelial cells, but how other features of the tumor env...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158050/ https://www.ncbi.nlm.nih.gov/pubmed/27977771 http://dx.doi.org/10.1371/journal.pone.0168334 |