IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for g...

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Detalles Bibliográficos
Autores principales: Slaats, Jeroen, ten Oever, Jaap, van de Veerdonk, Frank L., Netea, Mihai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158075/
https://www.ncbi.nlm.nih.gov/pubmed/27977798
http://dx.doi.org/10.1371/journal.ppat.1005973
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author Slaats, Jeroen
ten Oever, Jaap
van de Veerdonk, Frank L.
Netea, Mihai G.
author_facet Slaats, Jeroen
ten Oever, Jaap
van de Veerdonk, Frank L.
Netea, Mihai G.
author_sort Slaats, Jeroen
collection PubMed
description The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers.
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spelling pubmed-51580752016-12-21 IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections Slaats, Jeroen ten Oever, Jaap van de Veerdonk, Frank L. Netea, Mihai G. PLoS Pathog Review The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers. Public Library of Science 2016-12-15 /pmc/articles/PMC5158075/ /pubmed/27977798 http://dx.doi.org/10.1371/journal.ppat.1005973 Text en © 2016 Slaats et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Slaats, Jeroen
ten Oever, Jaap
van de Veerdonk, Frank L.
Netea, Mihai G.
IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections
title IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections
title_full IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections
title_fullStr IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections
title_full_unstemmed IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections
title_short IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections
title_sort il-1β/il-6/crp and il-18/ferritin: distinct inflammatory programs in infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158075/
https://www.ncbi.nlm.nih.gov/pubmed/27977798
http://dx.doi.org/10.1371/journal.ppat.1005973
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