Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines

Autophagy, a self-digestive system for cytoplasmic components, is required to maintain the amino acid pool for cellular homeostasis. We previously reported that the macrolide antibiotics azithromycin (AZM) and clarithromycin (CAM) have an inhibitory effect on autophagy flux, and they potently enhanc...

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Detalles Bibliográficos
Autores principales: Hirasawa, Kazuhiro, Moriya, Shota, Miyahara, Kana, Kazama, Hiromi, Hirota, Ayako, Takemura, Jun, Abe, Akihisa, Inazu, Masato, Hiramoto, Masaki, Tsukahara, Kiyoaki, Miyazawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158196/
https://www.ncbi.nlm.nih.gov/pubmed/27977675
http://dx.doi.org/10.1371/journal.pone.0164529

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