RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1

The retinoblastoma (RB) tumor suppressor is recognized as a master regulator that controls entry into the S phase of the cell cycle. Its loss leads to uncontrolled cell proliferation and is a hallmark of cancer. RB works by binding to members of the E2F family of transcription factors and recruiting...

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Detalles Bibliográficos
Autores principales: Vélez-Cruz, Renier, Manickavinayaham, Swarnalatha, Biswas, Anup K., Clary, Regina Weaks, Premkumar, Tolkappiyan, Cole, Francesca, Johnson, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159665/
https://www.ncbi.nlm.nih.gov/pubmed/27940962
http://dx.doi.org/10.1101/gad.288282.116

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