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The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

Noncanonical mechanistic target of rapamycin (mTOR) pathways remain poorly understood. Mutations in the tumor suppressor folliculin (FLCN) cause Birt-Hogg-Dubé syndrome, a hamartomatous disease marked by mitochondria-rich kidney tumors. FLCN functionally interacts with mTOR and is expressed in most...

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Detalles Bibliográficos
Autores principales:	Wada, Shogo, Neinast, Michael, Jang, Cholsoon, Ibrahim, Yasir H., Lee, Gina, Babu, Apoorva, Li, Jian, Hoshino, Atsushi, Rowe, Glenn C., Rhee, James, Martina, José A., Puertollano, Rosa, Blenis, John, Morley, Michael, Baur, Joseph A., Seale, Patrick, Arany, Zoltan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159669/ https://www.ncbi.nlm.nih.gov/pubmed/27913603 http://dx.doi.org/10.1101/gad.287953.116

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