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Across-cohort QC analyses of GWAS summary statistics from complex traits

Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires large genome-wide association meta-analyses (GWAMAs) to maximize statistica...

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Detalles Bibliográficos
Autores principales: Chen, Guo-Bo, Lee, Sang Hong, Robinson, Matthew R, Trzaskowski, Maciej, Zhu, Zhi-Xiang, Winkler, Thomas W, Day, Felix R, Croteau-Chonka, Damien C, Wood, Andrew R, Locke, Adam E, Kutalik, Zoltán, Loos, Ruth J F, Frayling, Timothy M, Hirschhorn, Joel N, Yang, Jian, Wray, Naomi R, Visscher, Peter M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159754/
https://www.ncbi.nlm.nih.gov/pubmed/27552965
http://dx.doi.org/10.1038/ejhg.2016.106