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IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure
Pro-inflammatory mediators are identified in patients with heart failure (HF), some of which may be used as biomarkers with diagnostic or prognostic value. As an additional ligand of Colony Stimulating Factor-1 Receptor (CSF-1R), interleukin-34 (IL-34) has been identified as a pro-inflammatory cytok...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159784/ https://www.ncbi.nlm.nih.gov/pubmed/27982136 http://dx.doi.org/10.1038/srep39324 |
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author | Fan, Qin Yan, Xiaoxiang Zhang, Hang Lu, Lin Zhang, Qi Wang, Fang Xi, Rui Hu, Jian Chen, Qiujing Niu, Wenquan Shen, Weifeng Zhang, Ruiyan Tao, Rong |
author_facet | Fan, Qin Yan, Xiaoxiang Zhang, Hang Lu, Lin Zhang, Qi Wang, Fang Xi, Rui Hu, Jian Chen, Qiujing Niu, Wenquan Shen, Weifeng Zhang, Ruiyan Tao, Rong |
author_sort | Fan, Qin |
collection | PubMed |
description | Pro-inflammatory mediators are identified in patients with heart failure (HF), some of which may be used as biomarkers with diagnostic or prognostic value. As an additional ligand of Colony Stimulating Factor-1 Receptor (CSF-1R), interleukin-34 (IL-34) has been identified as a pro-inflammatory cytokine participating in chronic heart failure (CHF). However, the potential impact of IL-34 in CHF complications remains unknown. In order to determine the clinical significance of serum IL-34 in CHF patients, especially those with kidney dysfunction and coronary artery disease (CAD) comorbid conditions, serum IL-34 was measured in 510 consecutive patients with CHF in a cross-sectional study. The present study demonstrated that higher serum IL-34 levels were associated with poorer renal function and more severe anemia in patients with CHF. After adjusting for age, gender, conventional risk factors, and other significant covariates, IL-34 positively correlated with the presence and severity of renal dysfunction (as measured by eGFR and cystatin C) on multivariable linear and logistic regression analysis. IL-34 was also demonstrated to be an independent risk factor for CAD among HF patients. In conclusion, elevated serum IL-34 levels were demonstrated to be independently associated with renal insufficiency and CAD in patients with CHF, regardless of the systolic function. |
format | Online Article Text |
id | pubmed-5159784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51597842016-12-21 IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure Fan, Qin Yan, Xiaoxiang Zhang, Hang Lu, Lin Zhang, Qi Wang, Fang Xi, Rui Hu, Jian Chen, Qiujing Niu, Wenquan Shen, Weifeng Zhang, Ruiyan Tao, Rong Sci Rep Article Pro-inflammatory mediators are identified in patients with heart failure (HF), some of which may be used as biomarkers with diagnostic or prognostic value. As an additional ligand of Colony Stimulating Factor-1 Receptor (CSF-1R), interleukin-34 (IL-34) has been identified as a pro-inflammatory cytokine participating in chronic heart failure (CHF). However, the potential impact of IL-34 in CHF complications remains unknown. In order to determine the clinical significance of serum IL-34 in CHF patients, especially those with kidney dysfunction and coronary artery disease (CAD) comorbid conditions, serum IL-34 was measured in 510 consecutive patients with CHF in a cross-sectional study. The present study demonstrated that higher serum IL-34 levels were associated with poorer renal function and more severe anemia in patients with CHF. After adjusting for age, gender, conventional risk factors, and other significant covariates, IL-34 positively correlated with the presence and severity of renal dysfunction (as measured by eGFR and cystatin C) on multivariable linear and logistic regression analysis. IL-34 was also demonstrated to be an independent risk factor for CAD among HF patients. In conclusion, elevated serum IL-34 levels were demonstrated to be independently associated with renal insufficiency and CAD in patients with CHF, regardless of the systolic function. Nature Publishing Group 2016-12-16 /pmc/articles/PMC5159784/ /pubmed/27982136 http://dx.doi.org/10.1038/srep39324 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Fan, Qin Yan, Xiaoxiang Zhang, Hang Lu, Lin Zhang, Qi Wang, Fang Xi, Rui Hu, Jian Chen, Qiujing Niu, Wenquan Shen, Weifeng Zhang, Ruiyan Tao, Rong IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure |
title | IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure |
title_full | IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure |
title_fullStr | IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure |
title_full_unstemmed | IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure |
title_short | IL-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure |
title_sort | il-34 is associated with the presence and severity of renal dysfunction and coronary artery disease in patients with heart failure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159784/ https://www.ncbi.nlm.nih.gov/pubmed/27982136 http://dx.doi.org/10.1038/srep39324 |
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