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Efficient generation of B2m-null pigs via injection of zygote with TALENs

Donor major histocompatibility complex class I (MHC I) molecules are the main targets of the host immune response after organ allotransplantation. Whether and how MHC I-deficiency of pig donor tissues affects rejection after xenotransplantation has not been assessed. Beta2-microglobulin (B2M) is ind...

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Detalles Bibliográficos
Autores principales:	Wang, Yong, Du, Yinan, Zhou, Xiaoyang, Wang, Lulu, Li, Jian, Wang, Fengchao, Huang, Zhengen, Huang, Xingxu, Wei, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159787/ https://www.ncbi.nlm.nih.gov/pubmed/27982048 http://dx.doi.org/10.1038/srep38854

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