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Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116 cells

Hypoxia-inducible factor-1 (HIF-1) is an important transcription factor that induces adaptive responses upon low oxygen conditions in human cancers and triggers off a poor prognostic outcome of conventional treatments. In this study, we discovered for the first time that brusatol (BRU), a quassinoid...

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Detalles Bibliográficos
Autores principales:	Lu, Yapeng, Wang, Bo, Shi, Qian, Wang, Xueting, Wang, Dang, Zhu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159874/ https://www.ncbi.nlm.nih.gov/pubmed/27982118 http://dx.doi.org/10.1038/srep39123

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