Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D

Since about 30% of all human cancers contain mutationally activated Ras, down regulating the over-activation of Ras/MAPK pathway represents a viable approach for treating cancers. Over-activation of Ras/MAPK pathway is accompanied by accumulation of reactive oxygen species (ROS). One approach for de...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Zhi, Dejuan, Li, Menghui, Liu, Dongling, Wang, Xin, Wu, Zhengrong, Zhang, Zhanxin, Fei, Dongqing, Li, Yang, Zhu, Hongmei, Xie, Qingjian, Yang, Hui, Li, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159904/
https://www.ncbi.nlm.nih.gov/pubmed/27982058
http://dx.doi.org/10.1038/srep38934

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