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Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone

BACKGROUND: The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. METH...

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Detalles Bibliográficos
Autores principales: Dou, Honglei, Wang, Guowei, Xing, Na, Zhang, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159971/
https://www.ncbi.nlm.nih.gov/pubmed/27978849
http://dx.doi.org/10.1186/s13018-016-0492-9
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author Dou, Honglei
Wang, Guowei
Xing, Na
Zhang, Lina
author_facet Dou, Honglei
Wang, Guowei
Xing, Na
Zhang, Lina
author_sort Dou, Honglei
collection PubMed
description BACKGROUND: The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. METHODS: Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing. RESULTS: The therapeutic effect in the test group was superior to that in the control group. CONCLUSIONS: Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects.
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spelling pubmed-51599712016-12-23 Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone Dou, Honglei Wang, Guowei Xing, Na Zhang, Lina J Orthop Surg Res Research Article BACKGROUND: The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. METHODS: Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing. RESULTS: The therapeutic effect in the test group was superior to that in the control group. CONCLUSIONS: Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects. BioMed Central 2016-12-15 /pmc/articles/PMC5159971/ /pubmed/27978849 http://dx.doi.org/10.1186/s13018-016-0492-9 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Dou, Honglei
Wang, Guowei
Xing, Na
Zhang, Lina
Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
title Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
title_full Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
title_fullStr Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
title_full_unstemmed Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
title_short Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
title_sort repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159971/
https://www.ncbi.nlm.nih.gov/pubmed/27978849
http://dx.doi.org/10.1186/s13018-016-0492-9
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