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Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone
BACKGROUND: The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. METH...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159971/ https://www.ncbi.nlm.nih.gov/pubmed/27978849 http://dx.doi.org/10.1186/s13018-016-0492-9 |
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author | Dou, Honglei Wang, Guowei Xing, Na Zhang, Lina |
author_facet | Dou, Honglei Wang, Guowei Xing, Na Zhang, Lina |
author_sort | Dou, Honglei |
collection | PubMed |
description | BACKGROUND: The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. METHODS: Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing. RESULTS: The therapeutic effect in the test group was superior to that in the control group. CONCLUSIONS: Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects. |
format | Online Article Text |
id | pubmed-5159971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-51599712016-12-23 Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone Dou, Honglei Wang, Guowei Xing, Na Zhang, Lina J Orthop Surg Res Research Article BACKGROUND: The objective of this study was to investigate the therapeutic effects of the application of fascial flap-wrapped allogeneic bone for repair of large segmental tibial defects in rabbits and provide a theoretical basis for treatment of large segmental defects in weight-bearing bones. METHODS: Forty-eight healthy adult New Zealand White (NZW) rabbits were randomized into two groups to establish 15-mm bone defects in the proximal tibia. Bone defects in test and control groups were repaired using allogeneic bone with and without a vascularized fascial flap from the rabbit proximal tibia, respectively. The differences in repair of bone defects between the two groups were assessed with postoperative X-ray examination, new bone quantity assessment, serum bone Gla protein (BGP) level, and biomechanical testing. RESULTS: The therapeutic effect in the test group was superior to that in the control group. CONCLUSIONS: Fascial flap-wrapped allogeneic bone is superior to allogeneic bone alone, and is ideal for the treatment of large segmental bone defects. BioMed Central 2016-12-15 /pmc/articles/PMC5159971/ /pubmed/27978849 http://dx.doi.org/10.1186/s13018-016-0492-9 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Dou, Honglei Wang, Guowei Xing, Na Zhang, Lina Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
title | Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
title_full | Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
title_fullStr | Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
title_full_unstemmed | Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
title_short | Repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
title_sort | repair of large segmental bone defects with fascial flap-wrapped allogeneic bone |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159971/ https://www.ncbi.nlm.nih.gov/pubmed/27978849 http://dx.doi.org/10.1186/s13018-016-0492-9 |
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