P53-MDM2 Pathway: Evidences for A New Targeted Therapeutic Approach in B-Acute Lymphoblastic Leukemia

The tumor suppressor p53 is a canonical regulator of different biological functions, like apoptosis, cell cycle arrest, DNA repair, and genomic stability. This gene is frequently altered in human tumors generally by point mutations or deletions. Conversely, in acute lymphoblastic leukemia (ALL) geno...

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Detalles Bibliográficos
Autores principales: Trino, Stefania, De Luca, Luciana, Laurenzana, Ilaria, Caivano, Antonella, Del Vecchio, Luigi, Martinelli, Giovanni, Musto, Pellegrino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159974/
https://www.ncbi.nlm.nih.gov/pubmed/28018226
http://dx.doi.org/10.3389/fphar.2016.00491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159974/
https://www.ncbi.nlm.nih.gov/pubmed/28018226
http://dx.doi.org/10.3389/fphar.2016.00491

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