CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia

CD34 and CD38 proteins are usually used as surface markers to identify HSCs and Leukemic stem cells. However, there have been cases that lacked CD34 or CD38 protein but still had leukemia initiating capacity in B-ALL suggesting the restrictive of these two markers. CD34 and CD38 expression were dete...

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Detalles Bibliográficos
Autores principales: Jiang, Zhiwu, Wu, Di, Lin, Shouheng, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159997/
https://www.ncbi.nlm.nih.gov/pubmed/28018598
http://dx.doi.org/10.1186/s40364-016-0080-5
Descripción
Sumario:CD34 and CD38 proteins are usually used as surface markers to identify HSCs and Leukemic stem cells. However, there have been cases that lacked CD34 or CD38 protein but still had leukemia initiating capacity in B-ALL suggesting the restrictive of these two markers. CD34 and CD38 expression were detected in most B-ALL and can serve as a specific biomarker for the prognosis of this subset of leukemia. Lack of CD34 or high CD38 expression is associated with favorable prognosis.

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