CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia

CD34 and CD38 proteins are usually used as surface markers to identify HSCs and Leukemic stem cells. However, there have been cases that lacked CD34 or CD38 protein but still had leukemia initiating capacity in B-ALL suggesting the restrictive of these two markers. CD34 and CD38 expression were dete...

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Detalles Bibliográficos
Autores principales: Jiang, Zhiwu, Wu, Di, Lin, Shouheng, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159997/
https://www.ncbi.nlm.nih.gov/pubmed/28018598
http://dx.doi.org/10.1186/s40364-016-0080-5
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author Jiang, Zhiwu
Wu, Di
Lin, Shouheng
Li, Peng
author_facet Jiang, Zhiwu
Wu, Di
Lin, Shouheng
Li, Peng
author_sort Jiang, Zhiwu
collection PubMed
description CD34 and CD38 proteins are usually used as surface markers to identify HSCs and Leukemic stem cells. However, there have been cases that lacked CD34 or CD38 protein but still had leukemia initiating capacity in B-ALL suggesting the restrictive of these two markers. CD34 and CD38 expression were detected in most B-ALL and can serve as a specific biomarker for the prognosis of this subset of leukemia. Lack of CD34 or high CD38 expression is associated with favorable prognosis.
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spelling pubmed-51599972016-12-23 CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia Jiang, Zhiwu Wu, Di Lin, Shouheng Li, Peng Biomark Res Review CD34 and CD38 proteins are usually used as surface markers to identify HSCs and Leukemic stem cells. However, there have been cases that lacked CD34 or CD38 protein but still had leukemia initiating capacity in B-ALL suggesting the restrictive of these two markers. CD34 and CD38 expression were detected in most B-ALL and can serve as a specific biomarker for the prognosis of this subset of leukemia. Lack of CD34 or high CD38 expression is associated with favorable prognosis. BioMed Central 2016-12-16 /pmc/articles/PMC5159997/ /pubmed/28018598 http://dx.doi.org/10.1186/s40364-016-0080-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jiang, Zhiwu
Wu, Di
Lin, Shouheng
Li, Peng
CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia
title CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia
title_full CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia
title_fullStr CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia
title_full_unstemmed CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia
title_short CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia
title_sort cd34 and cd38 are prognostic biomarkers for acute b lymphoblastic leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159997/
https://www.ncbi.nlm.nih.gov/pubmed/28018598
http://dx.doi.org/10.1186/s40364-016-0080-5
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