Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

BACKGROUND: STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead to cell death. We tested whether an integrin-FAK-STAT3 signaling pathway we rece...

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Detalles Bibliográficos
Autores principales: Visavadiya, Nishant P., Keasey, Matthew P., Razskazovskiy, Vladislav, Banerjee, Kalpita, Jia, Cuihong, Lovins, Chiharu, Wright, Gary L., Hagg, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159999/
https://www.ncbi.nlm.nih.gov/pubmed/27978828
http://dx.doi.org/10.1186/s12964-016-0157-7

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