A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics

BACKGROUND: Amyloid-β 1–42 peptide (Aβ(1–42)) is associated with plaque formation in the brain of patients with Alzheimer’s disease (AD). Pharmacodynamic studies of AD therapeutics that lower the concentrations of Aβ(1–42) in peripheral blood require highly sensitive assays for its measurement. A di...

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Detalles Bibliográficos
Autores principales: Song, Linan, Lachno, D. Richard, Hanlon, David, Shepro, Adam, Jeromin, Andreas, Gemani, Dipika, Talbot, Jayne A., Racke, Margaret M., Dage, Jeffrey L., Dean, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5160015/
https://www.ncbi.nlm.nih.gov/pubmed/27978855
http://dx.doi.org/10.1186/s13195-016-0225-7

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