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Similar promotion of Aβ(1-42 )fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms
The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease. Apolipoprotein E deficient mice made transgenic for human apolipoprotein E ε4 accumulate excess cerebral amyloid when compared to similarly prepare...
Autores principales: | Sweeney, David, Martins, Ralph, LeVine, Harry, Smith, Jonathan D, Gandy, Sam |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516045/ https://www.ncbi.nlm.nih.gov/pubmed/15312232 http://dx.doi.org/10.1186/1742-2094-1-15 |
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