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Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments

Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in humans. A precondition for improved strategies to disrupt and/or reverse the damage is a credible explanatory mechanism for how toxicity phenomena emerge and converge to cause hepatic necrosis. The Target Phenomen...

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Detalles Bibliográficos
Autores principales:	Smith, Andrew K., Petersen, Brenden K., Ropella, Glen E. P., Kennedy, Ryan C., Kaplowitz, Neil, Ookhtens, Murad, Hunt, C. Anthony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161305/ https://www.ncbi.nlm.nih.gov/pubmed/27984590 http://dx.doi.org/10.1371/journal.pcbi.1005253

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