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Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

We report structural analysis of HIV protease variant PR(S17) which was rationally selected by machine learning to represent wide classes of highly drug-resistant variants. Crystal structures were solved of PR(S17) in the inhibitor-free form and in complex with antiviral inhibitor, darunavir. Despit...

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Detalles Bibliográficos
Autores principales:	Agniswamy, Johnson, Louis, John M., Roche, Julien, Harrison, Robert W., Weber, Irene T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161481/ https://www.ncbi.nlm.nih.gov/pubmed/27992544 http://dx.doi.org/10.1371/journal.pone.0168616

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