New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration

Skeletal muscle fibrosis and impaired muscle regeneration are major contributors to muscle wasting in Duchenne muscular dystrophy (DMD). Muscle growth is negatively regulated by myostatin (MSTN) and activins. Blockage of these pathways may improve muscle quality and function in DMD. Antisense oligon...

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Detalles Bibliográficos
Autores principales: Pasteuning-Vuhman, Svitlana, Boertje-van der Meulen, Johanna W., van Putten, Maaike, Overzier, Maurice, ten Dijke, Peter, Kiełbasa, Szymon M., Arindrarto, Wibowo, Wolterbeek, Ron, Lezhnina, Ksenia V., Ozerov, Ivan V., Aliper, Aleksandr M., Hoogaars, Willem M., Aartsma-Rus, Annemieke, Loomans, Cindy J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161514/
https://www.ncbi.nlm.nih.gov/pubmed/27733450
http://dx.doi.org/10.1096/fj.201600675R

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