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CGG Repeat-Induced FMR1 Silencing Depends on the Expansion Size in Human iPSCs and Neurons Carrying Unmethylated Full Mutations
In fragile X syndrome (FXS), CGG repeat expansion greater than 200 triplets is believed to trigger FMR1 gene silencing and disease etiology. However, FXS siblings have been identified with more than 200 CGGs, termed unmethylated full mutation (UFM) carriers, without gene silencing and disease sympto...
Autores principales: | Brykczynska, Urszula, Pecho-Vrieseling, Eline, Thiemeyer, Anke, Klein, Jessica, Fruh, Isabelle, Doll, Thierry, Manneville, Carole, Fuchs, Sascha, Iazeolla, Mariavittoria, Beibel, Martin, Roma, Guglielmo, Naumann, Ulrike, Kelley, Nicholas, Oakeley, Edward J., Mueller, Matthias, Gomez-Mancilla, Baltazar, Bühler, Marc, Tabolacci, Elisabetta, Chiurazzi, Pietro, Neri, Giovanni, Bouwmeester, Tewis, Di Giorgio, Francesco Paolo, Fodor, Barna D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161530/ https://www.ncbi.nlm.nih.gov/pubmed/27840045 http://dx.doi.org/10.1016/j.stemcr.2016.10.004 |
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