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Locus coeruleus and dopaminergic consolidation of everyday memory
The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161591/ https://www.ncbi.nlm.nih.gov/pubmed/27602521 http://dx.doi.org/10.1038/nature19325 |
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author | Takeuchi, Tomonori Duszkiewicz, Adrian J. Sonneborn, Alex Spooner, Patrick A. Yamasaki, Miwako Watanabe, Masahiko Smith, Caroline C. Fernández, Guillén Deisseroth, Karl Greene, Robert W. Morris, Richard G. M. |
author_facet | Takeuchi, Tomonori Duszkiewicz, Adrian J. Sonneborn, Alex Spooner, Patrick A. Yamasaki, Miwako Watanabe, Masahiko Smith, Caroline C. Fernández, Guillén Deisseroth, Karl Greene, Robert W. Morris, Richard G. M. |
author_sort | Takeuchi, Tomonori |
collection | PubMed |
description | The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine hydroxylase-expressing (TH(+)) neurons in the ventral tegmental area (VTA). We report that neuronal firing in the locus coeruleus (LC) is especially sensitive to environmental novelty, LC-TH(+) neurons project more profusely than VTA-TH(+) neurons to the hippocampus, optogenetic activation of LC-TH(+) neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by VTA inactivation. Surprisingly, two effects of LC-TH(+) photoactivation are sensitive to hippocampal D(1)/D(5) receptor blockade and resistant to adrenoceptors blockade – memory enhancement and long lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, LC-TH(+) neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in hippocampus. |
format | Online Article Text |
id | pubmed-5161591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
record_format | MEDLINE/PubMed |
spelling | pubmed-51615912017-03-07 Locus coeruleus and dopaminergic consolidation of everyday memory Takeuchi, Tomonori Duszkiewicz, Adrian J. Sonneborn, Alex Spooner, Patrick A. Yamasaki, Miwako Watanabe, Masahiko Smith, Caroline C. Fernández, Guillén Deisseroth, Karl Greene, Robert W. Morris, Richard G. M. Nature Article The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine hydroxylase-expressing (TH(+)) neurons in the ventral tegmental area (VTA). We report that neuronal firing in the locus coeruleus (LC) is especially sensitive to environmental novelty, LC-TH(+) neurons project more profusely than VTA-TH(+) neurons to the hippocampus, optogenetic activation of LC-TH(+) neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by VTA inactivation. Surprisingly, two effects of LC-TH(+) photoactivation are sensitive to hippocampal D(1)/D(5) receptor blockade and resistant to adrenoceptors blockade – memory enhancement and long lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, LC-TH(+) neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in hippocampus. 2016-09-07 2016-09-15 /pmc/articles/PMC5161591/ /pubmed/27602521 http://dx.doi.org/10.1038/nature19325 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms Reprints and permissions information is available at www.nature.com/reprints. |
spellingShingle | Article Takeuchi, Tomonori Duszkiewicz, Adrian J. Sonneborn, Alex Spooner, Patrick A. Yamasaki, Miwako Watanabe, Masahiko Smith, Caroline C. Fernández, Guillén Deisseroth, Karl Greene, Robert W. Morris, Richard G. M. Locus coeruleus and dopaminergic consolidation of everyday memory |
title | Locus coeruleus and dopaminergic consolidation of everyday memory |
title_full | Locus coeruleus and dopaminergic consolidation of everyday memory |
title_fullStr | Locus coeruleus and dopaminergic consolidation of everyday memory |
title_full_unstemmed | Locus coeruleus and dopaminergic consolidation of everyday memory |
title_short | Locus coeruleus and dopaminergic consolidation of everyday memory |
title_sort | locus coeruleus and dopaminergic consolidation of everyday memory |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161591/ https://www.ncbi.nlm.nih.gov/pubmed/27602521 http://dx.doi.org/10.1038/nature19325 |
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