Diet restriction delays accelerated aging and genomic stress in DNA repair deficient mice

DNA repair-deficient Ercc1(Δ/−) mice show numerous accelerated aging features limiting lifespan to 4–6 month(1–4). Simultaneously they exhibit a ‘survival response’, which suppresses growth and enhances maintenance, resembling the anti-aging response induced by dietary restriction (DR)(1,5). Here we...

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Detalles Bibliográficos
Autores principales: Vermeij, W.P., Dollé, M.E.T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C.R., Wu, H., Roks, A.J.M., Botter, S.M., van der Eerden, B.C., Youssef, S.A., Kuiper, R.V., Nagarajah, B., van Oostrom, C.T., Brandt, R.M.C., Barnhoorn, S., Imholz, S., Pennings, J.L.A., de Bruin, A., Gyenis, Á., Pothof, J., Vijg, J., van Steeg, H., Hoeijmakers, J.H.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161687/
https://www.ncbi.nlm.nih.gov/pubmed/27556946
http://dx.doi.org/10.1038/nature19329

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