Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells

Dynamic spatiotemporal modification of chromatin around DNA damage is vital for efficient DNA repair. Normal stem cells exhibit an attenuated DNA damage response (DDR), inefficient DNA repair, and high radiosensitivity. The impact of unique chromatin characteristics of stem cells in DDR regulation i...

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Detalles Bibliográficos
Autores principales: Meyer, Barbara, Fabbrizi, Maria Rita, Raj, Suyash, Zobel, Cheri L., Hallahan, Dennis E., Sharma, Girdhar G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161741/
https://www.ncbi.nlm.nih.gov/pubmed/27974220
http://dx.doi.org/10.1016/j.stemcr.2016.11.004

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