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Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

The therapeutic effects of mesenchymal stem cell (MSC) transplantation following spinal cord injury (SCI) to date have been limited. Therefore, we aimed to enhance the immunomodulatory properties of MSCs via continuous secretion of the anti-inflammatory cytokine interleukin-13 (IL-13). By using MSCs...

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Detalles Bibliográficos
Autores principales: Dooley, Dearbhaile, Lemmens, Evi, Vangansewinkel, Tim, Le Blon, Debbie, Hoornaert, Chloé, Ponsaerts, Peter, Hendrix, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161742/
https://www.ncbi.nlm.nih.gov/pubmed/27974221
http://dx.doi.org/10.1016/j.stemcr.2016.11.005