LAPTM4B: an oncogene in various solid tumors and its functions

The oncogene Lysosome-associated protein transmembrane-4β (LAPTM4B) gene was identified, and the polymorphism region in the 5′-UTR of this gene was certified to be associated with tumor susceptibility. LAPTM4B-35 protein was found to be highly expressed in various solid tumors and could be a poor pr...

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Autores principales: Meng, Y, Wang, L, Chen, D, Chang, Y, Zhang, M, XU, J-J, Zhou, R, Zhang, Q-Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161753/
https://www.ncbi.nlm.nih.gov/pubmed/27212036
http://dx.doi.org/10.1038/onc.2016.189
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author Meng, Y
Wang, L
Chen, D
Chang, Y
Zhang, M
XU, J-J
Zhou, R
Zhang, Q-Y
author_facet Meng, Y
Wang, L
Chen, D
Chang, Y
Zhang, M
XU, J-J
Zhou, R
Zhang, Q-Y
author_sort Meng, Y
collection PubMed
description The oncogene Lysosome-associated protein transmembrane-4β (LAPTM4B) gene was identified, and the polymorphism region in the 5′-UTR of this gene was certified to be associated with tumor susceptibility. LAPTM4B-35 protein was found to be highly expressed in various solid tumors and could be a poor prognosis marker. The functions of LAPTM4B in solid tumors were also explored. It is suggested that LAPTM4B could promote the proliferation of tumor cells, boost invasion and metastasis, resist apoptosis, initiate autophagy and assist drug resistance.
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spelling pubmed-51617532017-01-05 LAPTM4B: an oncogene in various solid tumors and its functions Meng, Y Wang, L Chen, D Chang, Y Zhang, M XU, J-J Zhou, R Zhang, Q-Y Oncogene Review The oncogene Lysosome-associated protein transmembrane-4β (LAPTM4B) gene was identified, and the polymorphism region in the 5′-UTR of this gene was certified to be associated with tumor susceptibility. LAPTM4B-35 protein was found to be highly expressed in various solid tumors and could be a poor prognosis marker. The functions of LAPTM4B in solid tumors were also explored. It is suggested that LAPTM4B could promote the proliferation of tumor cells, boost invasion and metastasis, resist apoptosis, initiate autophagy and assist drug resistance. Nature Publishing Group 2016-12-15 2016-05-23 /pmc/articles/PMC5161753/ /pubmed/27212036 http://dx.doi.org/10.1038/onc.2016.189 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Review
Meng, Y
Wang, L
Chen, D
Chang, Y
Zhang, M
XU, J-J
Zhou, R
Zhang, Q-Y
LAPTM4B: an oncogene in various solid tumors and its functions
title LAPTM4B: an oncogene in various solid tumors and its functions
title_full LAPTM4B: an oncogene in various solid tumors and its functions
title_fullStr LAPTM4B: an oncogene in various solid tumors and its functions
title_full_unstemmed LAPTM4B: an oncogene in various solid tumors and its functions
title_short LAPTM4B: an oncogene in various solid tumors and its functions
title_sort laptm4b: an oncogene in various solid tumors and its functions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161753/
https://www.ncbi.nlm.nih.gov/pubmed/27212036
http://dx.doi.org/10.1038/onc.2016.189
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