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A steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation

BACKGROUND: The phenomenon of switch-like response to graded input signal is the theme involved in various signaling pathways in living systems. Positive feedback loops or double negative feedback loops embedded with nonlinearity exhibit these switch-like bistable responses. Such feedback regulation...

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Detalles Bibliográficos
Autores principales:	Giri, Lopamudra, Mutalik, Vivek K, Venkatesh, KV
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516236/ https://www.ncbi.nlm.nih.gov/pubmed/15291972 http://dx.doi.org/10.1186/1742-4682-1-2

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