C3 glomerulopathy in adults: a distinct patient subset showing frequent association with monoclonal gammopathy and poor renal outcome

BACKGROUND: C3 glomerulopathy (C3G) includes both C3 glomerulonephritis (C3GN) and dense deposit disease (DDD) and is defined by C3-dominant deposits on immunofluorescence. Dysfunction of the alternative pathway (AP) of complement is central to the pathophysiology of C3G and young patients often har...

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Detalles Bibliográficos
Autores principales: Lloyd, Isaac E., Gallan, Alexander, Huston, Hunter K., Raphael, Kalani L., Miller, Dylan V., Revelo, Monica P., Khalighi, Mazdak A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Glomerulopathies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162413/
https://www.ncbi.nlm.nih.gov/pubmed/27994856
http://dx.doi.org/10.1093/ckj/sfw090

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