Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells

BACKGROUND: Infection of intestinal epithelial cells by pathogenic Salmonella leads to activation of signaling cascades that ultimately initiate the proinflammatory gene program. The transcription factor NF-κB is a key regulator/activator of this gene program and is potently activated. We explored t...

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Detalles Bibliográficos
Autores principales: Tallant, Thomas, Deb, Amitabha, Kar, Niladri, Lupica, Joseph, de Veer, Michael J, DiDonato, Joseph A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516440/
https://www.ncbi.nlm.nih.gov/pubmed/15324458
http://dx.doi.org/10.1186/1471-2180-4-33

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