Trans-presentation of interleukin-6 by dendritic cells is required for priming pathogenic T(H)17 cells

The cellular sources of interleukin-6 (IL-6) that are relevant for the differentiation of T(H)17 cells remain unclear. Here, we used a novel strategy of IL-6 conditional deletion of distinct IL-6-producing cell types to show that Sirpα(+) dendritic cells (DC) were essential for the generation of pat...

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Detalles Bibliográficos
Autores principales: Heink, Sylvia, Yogev, Nir, Garbers, Christoph, Herwerth, Marina, Aly, Lilian, Gasperi, Christiane, Husterer, Veronika, Croxford, Andrew L., Möller-Hackbarth, Katja, Bartsch, Harald S., Sotlar, Karl, Krebs, Stefan, Regen, Tommy, Blum, Helmut, Hemmer, Bernhard, Misgeld, Thomas, Wunderlich, Thomas F., Hidalgo, Juan, Oukka, Mohamed, Rose-John, Stefan, Schmidt-Supprian, Marc, Waisman, Ari, Korn, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164931/
https://www.ncbi.nlm.nih.gov/pubmed/27893700
http://dx.doi.org/10.1038/ni.3632

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