No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy

The ATG8 family LC3/GABARAP proteins are attached to the membrane of nascent autophagosomes, but their functions during autophagy are unclear. In this issue, Nguyen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607039) show that LC3/GABARAP proteins are not essential for autophagosome f...

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Detalles Bibliográficos
Autor principal: Martens, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166506/
https://www.ncbi.nlm.nih.gov/pubmed/27888204
http://dx.doi.org/10.1083/jcb.201611116
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author Martens, Sascha
author_facet Martens, Sascha
author_sort Martens, Sascha
collection PubMed
description The ATG8 family LC3/GABARAP proteins are attached to the membrane of nascent autophagosomes, but their functions during autophagy are unclear. In this issue, Nguyen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607039) show that LC3/GABARAP proteins are not essential for autophagosome formation but are critical for autophagosome–lysosome fusion.
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spelling pubmed-51665062017-06-19 No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy Martens, Sascha J Cell Biol Commentary The ATG8 family LC3/GABARAP proteins are attached to the membrane of nascent autophagosomes, but their functions during autophagy are unclear. In this issue, Nguyen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607039) show that LC3/GABARAP proteins are not essential for autophagosome formation but are critical for autophagosome–lysosome fusion. The Rockefeller University Press 2016-12-19 /pmc/articles/PMC5166506/ /pubmed/27888204 http://dx.doi.org/10.1083/jcb.201611116 Text en © 2016 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Martens, Sascha
No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
title No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
title_full No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
title_fullStr No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
title_full_unstemmed No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
title_short No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
title_sort no atg8s, no problem? how lc3/gabarap proteins contribute to autophagy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166506/
https://www.ncbi.nlm.nih.gov/pubmed/27888204
http://dx.doi.org/10.1083/jcb.201611116
work_keys_str_mv AT martenssascha noatg8snoproblemhowlc3gabarapproteinscontributetoautophagy

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