ULK1 cycling: The ups and downs of the autophagy response

The Ser/Thr kinase ULK1/Atg1 controls autophagy initiation under nutrient starvation conditions. In this issue, Nazio et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605089) demonstrate that oscillatory modulation of NEDD4L-mediated proteasomal degradation and mTOR-dependent de novo prote...

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Detalles Bibliográficos
Autores principales: Zhao, Yan G., Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166507/
https://www.ncbi.nlm.nih.gov/pubmed/27932574
http://dx.doi.org/10.1083/jcb.201611177
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author Zhao, Yan G.
Zhang, Hong
author_facet Zhao, Yan G.
Zhang, Hong
author_sort Zhao, Yan G.
collection PubMed
description The Ser/Thr kinase ULK1/Atg1 controls autophagy initiation under nutrient starvation conditions. In this issue, Nazio et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605089) demonstrate that oscillatory modulation of NEDD4L-mediated proteasomal degradation and mTOR-dependent de novo protein synthesis of ULK1 ensures the proper amplitude and duration of the autophagy response during prolonged starvation, thus maintaining cellular homeostasis.
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spelling pubmed-51665072017-06-19 ULK1 cycling: The ups and downs of the autophagy response Zhao, Yan G. Zhang, Hong J Cell Biol Commentary The Ser/Thr kinase ULK1/Atg1 controls autophagy initiation under nutrient starvation conditions. In this issue, Nazio et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605089) demonstrate that oscillatory modulation of NEDD4L-mediated proteasomal degradation and mTOR-dependent de novo protein synthesis of ULK1 ensures the proper amplitude and duration of the autophagy response during prolonged starvation, thus maintaining cellular homeostasis. The Rockefeller University Press 2016-12-19 /pmc/articles/PMC5166507/ /pubmed/27932574 http://dx.doi.org/10.1083/jcb.201611177 Text en © 2016 Zhao and Zhang This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Zhao, Yan G.
Zhang, Hong
ULK1 cycling: The ups and downs of the autophagy response
title ULK1 cycling: The ups and downs of the autophagy response
title_full ULK1 cycling: The ups and downs of the autophagy response
title_fullStr ULK1 cycling: The ups and downs of the autophagy response
title_full_unstemmed ULK1 cycling: The ups and downs of the autophagy response
title_short ULK1 cycling: The ups and downs of the autophagy response
title_sort ulk1 cycling: the ups and downs of the autophagy response
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166507/
https://www.ncbi.nlm.nih.gov/pubmed/27932574
http://dx.doi.org/10.1083/jcb.201611177
work_keys_str_mv AT zhaoyang ulk1cyclingtheupsanddownsoftheautophagyresponse
AT zhanghong ulk1cyclingtheupsanddownsoftheautophagyresponse

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